MESA initiative has a 40-year history of successfully engaging and sustaining minority and disadvantaged students’ participation in STEM coursework, from elementary school to college campuses. Temple University has been awarded the national license to coordinate MESA in Pennsylvania, joining prestigious institutions like the University of California, University of Washington, the Johns Hopkins APL, University of Denver, and others offering statewide STEM initiatives to underrepresented groups. PA MESA joins Arizona, California, Colorado, Maryland, New Mexico, Oregon, Washington, and Utah. The program relies on socially and culturally relevant teaching strategies, community engagement, and industry partnerships. MESA is also unique in its approach to STEM, addressing national priority needs in IT/Cyber Security, Engines Design, Alternative Energy, and Health Professions. More than 45,000 students are served each year in MESA programs across the nation.